Alabama Strip Club Remains Open Despite Shooting, Declares They Will Call in Marines Before Closing

Don’t know, but there may be some hi-points in there.

A few Cialis sprinkled around the infield and and you get a mix of Styer 1912’s and Mauser C96’s.

Fully semi automatic.

That is statistically impossible. 20% of you will be incarcerated at some point.

Three words: Emergency Use Authorization. If treatments already exist, then how can a select few get really, really rich when the opportunity arises?

It was recently reported that pharma had been trying to get various forms of mRNA approved for some time pre-Covid. They never passed because of the side effects. Why wasn’t that reported? The reporting was that this was like any other vax that you had no problem getting, so get the vax rube! Safe and effective! The unvaxxed are killing your grandma! You won’t catch it if you just get the vax! Get it or you’re fired! I mean you won’t get sick if you get the vax. Get it or you’re fired! I mean you won’t die if you get the vax. Get it or you’re fired!

St. Fauci was honest and ethical. No regrets. Somehow he, along with a few others, made millions/billions during Covid. We shouldn’t notice these things. Look over there! Orange Man Bad said something!

“It was recently reported that pharma had been trying to get various forms of mRNA approved for some time pre-Covid. They never passed because of the side effects. Why wasn’t that reported?”

[Unsure what words are banned so I’m creating new ones that hopefully get past the moderation.]

People with good memories might remember that I got into it with someone here on this topic in the Spring of 2021. As it happens, the topic is pretty close to my current bailiwick.

They claimed that mRNA was in use since the mid 2000’s and was safe and told readers to look up a project they claimed to have knowledge of which used mRNA tech for vaxtech in the late 2000’s/early 2010’s.

The problem with that was it wasn’t really true. The poster immediately ceased to answer questions when confronted with actual biology questions. In short, I suspect that they were not lying but had smoke blown up their ass by a postdoc and couldn’t really tell the difference but that’s not really the point. The tech that they brought up did, in fact, exist but it had nothing to do with mRNA tech at all. It was an entirely different avenue of research involving GMOs to produce a viral antigen, purify huge quantities of it and make subunit jabs from that. One could see it almost as a precursor to NovaVax, which uses moth cells instead of plants to do the same basic thing.

From the actual literature and research:

This contains several threads. mRNA itself, delivery platforms and stabilization of the mRNA. These research lines start at different times and in different places but they intersect numerous times too. I’ll break this down in simplified terms a bit to avoid writing a couple dozen pages summarizing several thousand pages of papers.

mRNA as a “tech” starts in earnest around 2006 in Germany. It was being experimented with as a cancervax to prevent relapse in recovered patients at high risk for cancer recurrance.

Essentially they were taking a patient’s own cancer cells, extracting certain mRNAs and attempting to reinject them into a patient in a way that would alert the immune system to the tumor before it came back.

This work was mostly done on *cold, hard* tumors. That is tumors you’d think of as a mass but with little vascularization which makes it hard for the immune system to see them. Results were decidedly mixed and, as one might expect, a major problem was mRNA’s stability. It was very hard to extract mRNA and keep it whole until injection because the world is full of RNases. Where it was done it was purely using the material derived from the patient and it was done in a hospital because time and handling were critical. Temperature and time were also enemies here. mRNA just ain’t that stable, and again, the world is full of RNases. RNA is actually a huge PITA to work with in this regard. Ask me how I know.

This is, essentially, an attempt to use a subject’s own mRNA as a jab that presents an antigen of interest but also as a form of immunomodulation in some regards that aren’t really worth the discussion space here.

This work proceeds over time. Around 2014 you start to get certain ideas that a specialized carrier is needed for this kind of thing. That idea comes out of earlier work on AdV cancer treatments where people reprogrammed adenoviruses to attack cancer and inject lethal genetic code into the cells that tells the cell to commit to apoptosis (PCD hereafter, Programmed Cell Death).

AdV has its own set of challenges, not the least of which is that many cancers don’t have, so as was known at the time, unique cellular surface proteins. This means you don’t really have a cancer specific target for the virus to attach to and therefore basically have no targeting mechanism. You also run into a bunch of problems with the fact that cancers tend to have mutations that have shut off the exact safety systems that would normally kill the cells regardless of where that signal comes from in the world of DNA. Inter and intra cellular DNA based systems (that is apoptosis the cell commits to itself or that it is told to commit to by an external immune cell) do not function because certain parts of the machinery to process the DNA message are destroyed or offline. This means that using a dsDNA virus often won’t work because the ability to move from DNA->RNA->Protein is stopped at the first arrow.

mRNA allows you to jump past those issues, getting past all transcription machinery and straight to translation. In theory this bypasses nearly all of the cancer cell’s *safety shutdowns* and allows you to introduce a message that tells the cell to commit to PCD and off itself without much pro-inflammatory signaling going on.

But you have the same delivery problem. How do you get this message to the desired cells and only the desired cells?

That leads to work on the famous LNPs. Technically this work was started in the early 1990’s but all the LNPs back then were highly cytotoxic and untargeted. Meaning that they cause mass cell death regardless of the message contained and they do so stochastically but along a gradient where they’re mostly lost up front. Injection into a living creature causes necrosis (pro-inflammatory cell death) at the injection site with narrowing bands leading away from that site. Essentially, these things disrupted membrane architecture and caused a hole in the outside of the cell, which as you might imagine, is bad for the cell. It’s basically how several naturally occurring venoms work and they’re very good at producing necrosis.

Work on this front is on-again-off-again for years.

The current generation of LNP comes along ~2015 and is patented, IIRC in 2017. It uses a couple of cationic lipids that were being researched for other purposes up until about 2015 when someone noticed that they’d make a decent micelle if combined with other lipids. It also showed promise in not being flat-out cytotoxic on contact. These things didn’t disrupt the cellular membrane in a manner that blew a hole in the cells that uptook the package.

Again, no targeting mechanism but it is a semi-stable and uptake-able delivery package. It does, however, contain a couple of things that are not approved for use in animals or people according to the MSDS sheets from 2023 (I haven’t pulled them for 2024 yet but I’ve posted them here before).

With that platform in hand we again have to jump back to the mid 2000’s. In 2005 the winners of the 2023 Medicine/Physiology Nobel did their original work on pseudouridine. They followed that up with more research through 2010, IIRC.

Long story short, they proved that dendritic cells were less apt to attack in vitro manufactured mRNA that was pseudouridineated and that the mRNA itself lasted longer thereby producing more protein when given to live cells. The Nobel press release stated that this is “…due to the reduced activation of an enzyme that regulates protein production”. Yeah, that’s an RNase. What they’re telling you doesn’t have that much to do with protein production and has a lot to do with the inability of the cell to degrade the message itself.

Pseudouridination also reduced the inflammation signaling previously associated with external mRNA introduced to living cells. This last bit almost certainly being part of a viral defense mechanism that they were shutting off without realizing what it did. What they don’t mention here is that replacing every U in the code has, uh, unexpected results in terms of the half-life of the mRNA. It lasts A LOT longer than they expected, or at least claimed to expect.

These things were all being researched in the vein of cancer treatment until 2020 when they were combined and tossed out the door as a novel product for a respiratory illness.

The reason for that is because it’s fast. Something nearly no one, including myself, was aware of at the time is that USDOD has had an interest in jabs for biodefense for a couple of decades. In the early 2000’s they thought that it was becoming possible to whip up bioweapons in a basement lab and that defenses against rapidly produced novel pathogens was a good idea.

This led to the previously mentioned project, as presented by another poster, that wasn’t mRNA but took the production time for a new jab from a year down to ~5 months. Impressive but not fast enough against a true bioweapon. mRNA *promised* to take this down to a month or two.

Which is to say that from genetic sequencing of the pathogen to full scale production in 60 days if needed. This rapid response is what DOD was funding and working on.

CoV-2 was the “crisis” that greenlit this project jumping from pure research to actual use due to the overestimation of the threat.

The question is why that overestimation took place. I suspect that’s a combinatorial issue. Part CYA, part panic, part greed, part politics.

I think there were probably people freaking out that this was an actual bioweapon and not a leak. There was a lot of talk early on that this might cause a massive rise in cancer, like HPV or other herpies viruses can. Such people ignored or did not know of the dsDNA nature of the Herpesviridae family genome which is what allows it to hide out in cells for years and cause an increase in cancer risk.

I also think that such people were mostly ignorant of the GoF research going on and that the people doing that were trying to cover it up by becoming saviors.

I also think a lot of power politics was going on because Trump. Orangeman bad. If we gotta vent some people to death, well, that’s a small price to pay if it saves one election, right?

And then of course there’s the cash. All that cash.

But clearly the manufacturers knew that the product and the process to make it were experimental. Hence they indemnity they asked for (and got). They also changed the production process to scale it up and they knew damn well that would introduce impurities which they also knew damn well they didn’t do much to reduce because, well, they couldn’t and still have a product.

Modded. FML.

Oh well, at least it didn’t just disappear.

strych9,

I agree 100% with everything that you stated.

Making matters worse: my spouse and child did not get sick until August 2021 at which time medical science MOST DEFINITELY knew how to deal effectively with CoV-2 and somewhat inexplicably and intentionally chose not to.

By the way, any guesses how my spouse and children were all very ill with CoV-2, I was in close proximity to them for all two weeks of their severe illnesses, I was their constant (24/7) caretaker, I took two of them to the hospital, and I never got ill? Hint: I stumbled upon accurate CoV-2 information and initiated prophylactic measures as well as ongoing measures. The most sad aspect to my measures: I had to find a way to acquire certain items outside of doctors, hospitals, and pharmacies because my state threatened to prosecute them in civil and criminal courts if they assisted anyone with anything other than known ineffective treatments.

Oh, and I forgot to mention a very healthy friend of mine who was going to die from CoV-2. Several days after onset of symptoms, his fever was spiking in excess of 105 degrees, his blood oxygen level was falling into the low 80s, and he could not stop coughing. He returned to a premiere hospital system whose only treatment modality was a modest course of anti-inflammatory medication which was known to be ineffective. By happenstance he was a veteran and had a good friend who was an Emergency Room doctor at the local Veterans Administration hospital who learned about my friend’s condition. He told my friend to leave the premiere hospital and come to the Veterans Administration hospital where he would give my friend the synthetic antibodies that were recently available. Within 24 hours of receiving the synthetic antibodies at the VA hospital, my friend was almost back to normal health. We have no idea to this day why the local premiere hospital system refused to administer the synthetic antibodies.

oh wait, the 3rd Force Reconnaissance Company unit is actually in Fairhope about 25 minutes from Mobile. The recruiter address is 1630 S. Broad St. Mobile, AL. co located with the Army National Guard recruiter in Mobile, AL.